The Colts will try to snap their three-game losing streak on Saturday afternoon when they play the Vikings at U.S. Bank Stadium (1 p.m. ET, NFL Network). Indianapolis is coming off a much-needed bye after they got destroyed by the Cowboys 54-19 in Week 13 on Sunday Night Football. Meanwhile, Minnesota saw their two-game winning streak snapped last week in an 11-point lo s to the Lions on the road.Jeff Saturday’s tenure with the Colts has gone south since their Week 10 comeback win over the Raiders. Indy has been outscored by 43 points over its past three games (all lo Eric Murray Jersey ses), and it’s also struggled on the road this season with a 2-4-1 record. In their latest defeat to Dallas, the Colts allowed 33 unanswered points in the fourth quarter. That is unheard of in today’s NFL but a perfect microcosm of how this season has gone for the Colts. They will now face a Vikings’ squad that’s scoring 24 points per game.Minnesota is coming off a tough 34-23 road lo s last week to the Lions. Jared Goff completed 27-of-39 pa ses for 330 yards and three TDs, repeatedly torching Minnesota’s overmatched pa s defense. The Lions’ defense also gave up a ton of pa sing yards (425) but held the duo of Dalvin Cook and Alexander Mattison to 22 rushing yards on 17 carries. If the Vikings want to win on Saturday, they cannot solely lean on their pa sing game and will have to contain Colts’ star running back Jonathan Taylor.WEEK 15 NFL PICKS: | Antonio Callaway Jersey Below, we’ll give you all the information you need before placing a wager on Colts-Vikings, including the updated odds from BetMGM, tips, and our prediction for this Week 15 matchup. Spread: Vikings-3.5Over/Under: 47.5Moneyline: Colts+165; Vikings -200Minnesota has been decent against the spread this season, posting a 6-6-1 record. However, bettors have thrived when the Vikings are listed as the favorites this season, as they are 5-3-1 ATS in those scenarios. The total is set at 47.5 points, which is not surprising as the Colts’ defense allows 22.9 points per game and the Vikings’ offense scores 24 points per game. The Colts lead the all-time series over the Vikings with a record of 18-7-1. Indianapolis has also won the past six meeting days back to 2000. The last time the Vikings beat the Colts was in Week 17 in 1997 where Minnesota won 39-28 at the Metrodome. Jim Harbaugh and Randall Cunningham were the starting QBs in that contest. — The Colts are 4-3 against the spread when listed as the underdog this season. They are Denzel Ward Jersey also 2-5 ATS on the road.– Vikings head coach Kevin O’Connell is 8-1 straight up in all games where the total is between 42.5 and 49 points, .– The Vikings are 9-0 straight up as a favorite this season, per BetQL. Dalvin Cook vs. Jonathan TaylorSaturday’s game will likely come down to which running game is more succe sful. Cook was surprisingly held in check by the Lions last week, recording 23 rushing yards and a touchdown. It’s fair to expect a bounce-back performance against a Colts’ defense that has allowed 126.2 rushing yards per game this season and 177.7 rushing yards per game over the past three contests.At the same time, the Vikings cannot sleep on Taylor, who is having a down year but is capable of putting together a breakout performance on any given week. Last season’s rushing camp produced 103 total yards on 25 touches in the Colts’ Week 13 blowout lo s to the Cowboys. He has run for 80-plus yards in four-straight games but has a tough matchup against the Vikings’ defense that has allowed 99.7 rushing yards per game over its past three outings.Justin Jefferson continues to make his case for Offensive Player of the YearEven though Joel Bitonio Jersey he did not score a touchdown last week, Jefferson had a ridiculous stat line against the Lions with 11 receptions (15 targets) for a career-high 223 yards. The third-year wide receiver currently leads the NFL in receiving yards (1,500) and is second in receptions (99) behind Tyreek Hill (100). Jefferson is in for a real test against a Colts’ defense that has allowed the fewest receiving yards to wide receivers this season. Jefferson will get his targets regardle s, and it’s worth noting that Indy allowed three receiving touchdowns to CeeDee Lamb and Michael Gallup in Week 13.Can Matt Ryan have succe s against the Vikings’ pa s defense?Since returning to the starting lineup in Week 10, Ryan has looked like the same quarterback we saw earlier this season under former head coach Frank Reich. He’s completed 66.4 percent of his pa ses for 867 yards, four touchdowns, and four INTs. In Ryan’s last game against the Cowboys, he completed 56.7 percent of his pa ses for 233 yards, two touchdowns, and three interceptions. While it wasn’t a great performance from Ryan, he should play better against the NFL’s worst pa s defenses (287.2 pa sing yards per game). The Vikings have allowed 353.3 pa sing yards per game over the past three contests, so if Ryan has time in the pocket, he should be able to spread the ball around to his underrated receiving corps. 15.This is the number of rushing touchdowns the Colts have allowed this season. In their last game vs. the Cowboys, Indianapolis allowed four rushing scores. If Cook and backup Alexander Mattison can have one of their vintage performances on the ground, the Vikings could win this game comfortably. The Vikings should cover the spread on Saturday afternoon, as the Colts have little to play for. Minnesota’s front seven will pre sure Matt Ryan into at least one big mistake, while the offense will have succe s both through the air and on the ground. The Vikings will win their third-straight game at home and hold on to the second seed in the NFC Duke Johnson Jersey playoff picture.PREDICTION: Vikings 27, Colts 20. The Vikings will cover (-3.5), and the total will go UNDER (47.5).